Small Vessel Vasculitis and Cryglobulinemia

Our last report case involved a discussion of HCV related cryglobulinemic vasculitis. The illness script for this sort of patient would be a patient presenting with very acute (~24 hours onset) reddish rash on the lower extremities on a background of chronic infection (HIV/HCV) and/or malignancy (particularly lymphoma) found to have palpable purpura. 1. What is the differential diagnosis of purpura? Depends on whether the purpura is indurated or not. Induration is due to inflammation and leukocytoclasis, which has a very differential list of causes than nonpalpable purpura.

Our last report case involved a discussion of HCV related cryglobulinemic vasculitis. The illness script for this sort of patient would be a patient presenting with very acute (~24 hours onset) reddish rash on the lower extremities on a background of chronic infection (HIV/HCV) and/or malignancy (particularly lymphoma) found to have palpable purpura.

1. What is the differential diagnosis of purpura? Depends on whether the purpura is indurated or not. Induration is due to inflammation and leukocytoclasis, which has a very differential list of causes than nonpalpable purpura.

2. How do you treat HCV-related cryoglobulinemia? Treatment can be complex, but in general adheres to a fairly stepwise progression, the foundation being treat the underlying cause.

2. How do you treat HCV-related cryoglobulinemia? Treatment can be complex, but in general adheres to a fairly stepwise progression, the foundation being treat the underlying cause.