Lymphoma risk in patients treated with azathioprine

Learning points from noon report:

EBV+, diffuse large B cell lymphoma found in the liver and colon without lymphadenopathy, in the setting of UC, treated with azathioprine that was complicated by leukopenia. 

  • Lymphopenia is seen in ~5% of patients who are using azathioprine in the setting ulcerative colitis treatment

  • Lymphopenia increases your risk of viral infections as well as fungal infections.  The two most common infections seen are oral candidiasis and CMV colitis. 

  • There is an increased risk of Lymphoma in patients with IBD treated with azathioprine.  With a standardized incidence ratio for lymphoma of 4.92 (95% CI, 3.10-7.78).