Today Dr. Dreicer took us through an interesting case of a pregnant woman with MAHA and thrombocytopenia. We worked through a grid to help delineate the slight differences between a few items high on our differential. Attached is the table we created together in Noon Report.
Remember that sometimes it is important to label the group of signs and symptoms. For example, MAHA with thrombocytopenia. Because then, you have a key thing to build a differential for.
For additional information, please refer to the following references:
- George, J. Thrombotic Thrombocytopenic Purpura. N Engl J Med. 2006; 354:1927-1935
- Kappler, S. et al. Thrombotic Microangiopathies (TTP, HUS, HELLP). Emerg Med Clin N Am 32 (2014) 649–671.
- Pourrat, O. et al. Differentiation between severe HELLP syndrome and thrombotic microangiopathy, thrombotic thrombocytopenic purpura and other imitators. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2015. S0301-2115(15)00097-4
- Pourrat, O. et al. ADAMTS13 deficiency in severe postpartum HELLP syndrome. British Journal of Haematology, 2013, 163, 404–420.