Today we talked about an interesting patient from East Africa who presented with a chronic cough and was found to have eosinophilia. We discussed the differential for both eosinophilia and for hypoxia and eosinophilia.
1. The differential for hypereosinophilia and hypoxia:
-Acute eosinophilic pneumonia, simple pulmonary eosinophilia, chronic eosinophilic pneumonia
-Tropical Pulmonary Eosinophilia (Wuchereria bancrofti and Brugia malayi)
2. Chronic Eosinophilic Pneumonia:
-A rare interstitial lung disease with subacute or chronic symptoms, elevated blood and/or alveolar eosinophils, and often peripheral pulmonary infiltrates on imaging.
-Patients are often women (2:1), non-smokers, with peak incidence in the 50s, with the majority (50-60%) having asthma or atopy.
-Must rule out alternative diagnosis
-Treated with oral steroids. +/- inhaled corticosteroids.