Amyloidosis and MM

Dr. Myers presented a case today of abdominal fullness and LE edema ultimately found to have endomyocardial biopsy proven AL amyloidosis and multiple myeloma. This case prompted further investigation into the cardiac considerations when contemplating therapy for multiple myeloma (MM). This topic is discussed in a 2016 article in the American College of Cardiology along with a highlight of new MM therapies that do not have a strong cardiac signal. They conclude that as MM treatments continue to evolve (chimeric antigen T-cell therapy, bromodomain inhibitors, etc) that the field also needs to improve managment of cardiovascular risks and prevention strategies especially in light of the increased cardiovascular risk in this cohort at baseline.

 Review of CV risk factors in patients with MM from a  2016 ACC  article. 

Review of CV risk factors in patients with MM from a 2016 ACC article.